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Pulmonary embolism with floating right atrial thrombus successfully treated with streptokinase: a case report.

Massive pulmonary embolism (PE) is associated with significant mortality, especially if compounded by haemodynamic instability, right ventricular (RV) dysfunction and right atrial (RA) thrombus…

Treatment of Wide-Necked, Small Aneurysms With Pipeline Stent Results in High Occlusion Rates

By Alex Morrisson HOUSTON, Tex — February 28, 2017 — A new stent device makes it possible to protect patients found to have small to medium-sized wide-mouth brain aneurysms that have not ruptured, researchers reported here at the 2017 International Stroke Conference (ISC). After 1 year,…

Risk of Subsequent Malignancies Reduced Among Childhood Cancer Survivors

CHICAGO — February 28, 2017 — Although the risk of subsequent malignancies for survivors of childhood cancer diagnosed in the 1990s remains increased, the risk is lower compared with those diagnosed in the 1970s — a decrease that is associated with a reduction in therapeutic radiation dose,…

Increased Incidence Subdural Haematoma Linked to Increased Use of Anti-Clotting Drugs

CHICAGO — February 28, 2017 — An increased incidence in Denmark of subdural haematoma from 2000 to 2015 appears to be associated with the increased use of antithrombotic drugs, such as low-dose aspirin, vitamin K antagonists (VKAs), clopidogrel, and oral anticoagulants, according to a study…

Inactivity, Excess Weight Linked to Hard-to-Treat Heart Failure

DALLAS, Tex — February 28, 2017 — Lack of exercise and excessive weight are strongly associated with heart failure with preserved ejection fraction, according to a study published in the Journal of the American College of Cardiology (JACC). “Previous studies have consistently found an…

Neuroprotective Antibody Shows No Significant Impact on Walking After a Stroke

By Alex Morrisson HOUSTON, Tex — February 28, 2017 — An attempt to use an antibody to protect against nerve damage and improve patients’ walking ability after a stroke did not appear to improve outcomes, according to a study presented here at the 2017 International Stroke Conference (ISC)….

Patent Foramen Ovale Closure Device Shows Long-Term Benefit vs Medical Management in Stroke Prevention

By Alex Morrisson HOUSTON, Tex — February 28, 2017 — After a decade of follow-up, the use of patent foramen ovale (PFO) closure device appears to reduce the risk of stroke recurrence significantly better than medical treatment alone, according to a study presented here at the 2017 International…

Parkinson’s Disease May Have Link to Stroke

DALLAS, Tex — February 28, 2017 — Parkinson’s disease may be linked to stroke, much like Alzheimer’s disease and stroke are linked, according to research presented at the 2017 International Stroke Conference (ISC). To see if an association exists between stroke and Parkinson’s disease, Benjamin…

Taking Influenza Drugs During Pregnancy Does Not Increase Risk of Adverse Neonatal Outcomes

LONDON — March 1, 2017 — A study published by the BMJ finds no increased risks to newborn babies if their mothers have taken drugs to prevent or treat influenza during pregnancy. This is the largest study to date to assess potential risks of taking antiviral drugs during pregnancy and the…

Wireless Stimulation May Ease Migraine Pain as Well as Drugs

MINNEAPOLIS, Minn — March 1, 2017 — A wireless patch that you wear on your arm may help reduce migraine pain as well as drugs, according to a study published in the March 1, 2017, online issue of the journal Neurology. “These results need to be confirmed with additional studies, but they are…

Ultrasound-Guided Aspiration of Symptomatic Baker’s Cysts Reduces Pain

By Jill Stein VIENNA, Austria — March 1, 2017 — Aspiration of Baker’s cysts under ultrasound and fluoroscopic guidance followed by a therapeutic injection of methylprednisolone and bupivacaine reduces symptoms in most patients, according to a study presented here at the 2017 Annual European…

Children With Asthma More Likely to Become Obese

NEW YORK — January 20, 2017 — Children with asthma may be more likely to become obese later in childhood or in adolescence, according to a study published early online ahead of the print edition of the American Journal of Respiratory and Critical Care Medicine. Young children with asthma were 51…

Women’s Cognitive Decline Begins Earlier Than Previously Believed

LOS ANGELES — January 20, 2017 — Mental sharpness in women begins to decline as early as their 50s, according to a study published in PLOS ONE. The study, which followed the same group of healthy women for 10 years after menopause, found that their average decline in mental processing ability…

Lap Band Surgery Benefits Very Obese Adolescents

ADELAIDE, Australia — January 20, 2017 — Lap band surgery has significant benefits for severely obese teenagers and, despite its controversial nature, should still be considered as a first option to manage obesity during adolescence, according to a study published in the journal Obesity Surgery…

Use of Collagen Matrix for Diaphragm Reconstruction Reduces Need for Reoperation Due to Infections

By Ed Susman HOUSTON, Tex — January 24, 2017 — The use of an acellular dermal matrix for reconstruction of the diaphragm in patients undergoing surgery for mesothelioma appears to be associated with fewer re-operations than the use of polytetrafluoroethylene mesh, according to a study presented…

Anticoagulants May Be Unnecessary for Most Patients Undergoing Surgery

SALT LAKE CITY, Utah — January 24, 2017 — As many as 3 out of 4 surgery patients could be receiving anti-clotting medications that they do not need, according to a study published in the Annals of Surgery. The research challenges standard of care guidelines specifying that all patients…

Continuous Glucose Monitoring Improves Glucose Levels in Patients With Type 1 Diabetes

CHICAGO — January 24, 2017 — Two studies in the January 24/31 issue of JAMA find that continuous glucose monitoring (CGM) resulted in improved glucose levels in patients with type 1 diabetes who inject insulin multiple times a day. Only approximately 30% of individuals with type 1 diabetes meet…

Brain Scan Before Antidepressant Therapy May Predict Response

CHICAGO — January 24, 2017 — A functional magnetic resonance imaging (fMRI) brain scan may help predict which patients will respond positively to antidepressant therapy, according to a study published in the journal Brain. Researchers at the University of Illinois at Chicago, Chicago, Illinois,…

Critically Ill Children Don’t Benefit From Tight Blood Glucose Control

PHILADELPHIA — January 25, 2017 — Critically ill infants and children do not gain extra benefit from tight blood glucose control, according to a study published in the New England Journal of Medicine (NEJM). While both high and low levels of blood glucose control were relatively safe, control to…

Kidney Problems in Patients With DiGeorge Syndrome May Be Caused by Missing Gene

NEW YORK — January 25, 2017 — Loss of function of the CRKL gene causes kidney and urinary tract defects in people with DiGeorge syndrome, according to a study published in the New England Journal of Medicine (NEJM). “This study represents a critical step forward in understanding the genetic…

Treating Subclinical Hypothyroidism in Pregnant Women Can Reduce Risk of Pregnancy Loss

ROCHESTER, Minn — January 25, 2017 — Treating subclinical hypothyroidism in pregnant women can reduce the risk of pregnancy loss, especially for those with thyroid-stimulating hormone (TSH) levels on the upper end of normal or higher, according to a study published in BMJ. Pregnant women…

Gasserian Ganglion and Retrobulbar Nerve Block in the Treatment of Ophthalmic Postherpetic Neuralgia: A Case Report

88-year-old woman with severe ophthalmic division PHN after she failed to respond to conservative treatment…

Complete Regression of Psoriatic Arthritis after Belatacept conversion in a Highly HLA Sensitized kidney Transplant Patient

47-year-old man affected by a serious debilitating form of Psoriatic Arthritis presented during the course of a third, high…

Subcutaneous Dirofilariasis: A Masquerade of a Palisaded Granulomatous Dermatitis

49-year-old female who presented with an erythematous nodule on her shin, which closely resembled necrobiosis lipoidica on…

Portomesenteric venous thrombosis: A rare but probably under-reported complication of laparoscopic surgery: A case series

71-year-old morbidly obese woman admitted for elective laparoscopic giant hiatus hernia (LGHH) repair. Post-operatively,…

Biopsy-proven case of Epstein-Barr virus (EBV)-associated vasculitis of the central nervous system

75-year-old woman was admitted to our hospital with rapidly deteriorating consciousness disturbance. She had a 7-year history…

A Case of Refractory Systemic Capillary Leak Syndrome (Clarkson’s Disease) during Pregnancy

32-year-old woman, pregnant with twins, presented with a chief complaint of general fatigue. Her general condition had rapidly…

Retroperitoneal liposarcoma excreting insulin-like growth factor 2 that induced severe hypoglycemia

61-year-old man who complained of appetite loss and in whom a large mass in the retroperitoneum was detected. Despite having no history of diabetes mellitus, hypoglycemia suddenly occurred…

A Case of Hepatocellular Carcinoma Presenting as a Gingival Mass

50-year-old man, who was a chronic alcoholic and hepatitis B virus carrier, presented with abdominal distension and weight…

Pulmonary and tricuspid valvuloplasty in carcinoid heart disease

26-year-old female with carcinoid heart disease consisting of severe pulmonary and tricuspid valve stenosis was admitted…

Changes in Depression Symptoms Tied to Lung Cancer Survival

NEW HAVEN, Conn — October 14, 2016 — Worsening depression symptoms are associated with shorter survival for patients with lung cancer, particularly those in the early stages of disease, according to a study published in the Journal of Clinical Oncology. Conversely, when depression symptoms lift…

Hypothyroidism Symptoms Linger Despite Medication Use, Normal Blood Tests

CHICAGO — October 14, 2016 — Despite normal thyroid-stimulating hormone (TSH) tests, many patients with hypothyroidism still have many nagging symptoms of the disease, according to a study published in the Journal of Clinical Endocrinology and Metabolism. The study showed that individuals on…

Zika Virus Infection May Prevent Reinfection, Study Finds

MANHATTAN, Kan — October 14, 2016 — People infected with Zika virus may not be susceptible to Zika virus again, according to research published in the journal Nature Medicine. “The research shows that infection provides excellent protection against reinfection,” said Stephen Higgs, Kansas State…

Rare Mutation in the TM2D3 Gene Linked to Increased Risk, Earlier Onset of Alzheimer’s Disease

CAMBRIDGE, United Kingdom — October 17, 2016 — People with Icelandic heritage are more likely to carry a novel rare mutation in the TM2D3 gene, which leads to greater risk for Alzheimer’s disease, according to a study published in PLOS Genetics. While scientists have already identified…

Ziv-aflibercept Superior to Bevacizumab in Treating Diabetic Macular Oedema

By Michelle Dalton, ELS CHICAGO — October 18, 2016 — Both the 1.25-mg and the 2.5-mg dose of intravitreal ziv-aflibercept offered improvement from baseline in best corrected visual acuity (BCVA) in the treatment of diabetic macular oedema (DME) after 12 weeks compared with intravitreal…

Shorter Time Between Bariatric Surgery, Childbirth May Increase Risk of Complications for Infants

CHICAGO — October 19, 2016 — Infants who were born less than 2 years after a mother’s bariatric surgery had higher risks for prematurity, neonatal intensive care unit (NICU) admission, and small for gestational age status compared with longer intervals between bariatric surgery and childbirth,…

Long-Term Benefits of Aflibercept, Ranibizumab Similar in Patients With Diabetic Macular Oedema or Diabetic Retinopathy

By Michelle Dalton, ELS CHICAGO — October 19, 2016 — Investigators observed no additional benefit with aflibercept 2.0 mg over ranibizumab 0.3 mg on improvement of diabetic retinopathy (DR) in patients with diabetic macular oedema (DME) or diabetic retinopathy (DR), and no difference in…

Natalizumab Treatment Eases Depression in Patients With Multiple Sclerosis

By Alex Morrisson BALTIMORE, Maryland — October 19, 2016 — Treatment with natalizumab and interferon beta-1a appears to reduce symptoms of depression better than treatment with placebo and interferon beta-1a, according to a substudy of the SENTINEL clinical trial, presented at the 141st Annual…

Voriconazole More Effective Than Ketoconazole for Severe Fungal Keratitis

By Michelle Dalton CHICAGO — October 19, 2016 — In cases of severe fungal keratitis, the use of oral voriconazole as an adjunct to topical natamycin 5% is more effective than using oral ketoconazole, according to a study presented here at the 2016 Annual Meeting of the American Academy of…

Exercise May Ward Off Memory Decline in Patients With Vascular Cognitive Impairment

MINNEAPOLIS, Minn — October 19, 2016 — Exercise may be associated with a small benefit for elderly people who already have memory and thinking problems, according to a study published in the October 19, 2016, online issue of Neurology. The research involved people with vascular cognitive…

FDA Adds Boxed Warning to Direct-Acting Antivirals Due to Risk of HBV Reactivation

ROCKVILLE, Md — October 4, 2016 — The US Food and Drug Administration (FDA) is warning about the risk of hepatitis B virus (HBV) becoming an active infection again in any patient who has a current or previous infection with HBV and is treated with certain direct-acting antivirals (DAAs) medicines…

No Significant Difference Between 3 Oral Anticoagulants for Risk of Stroke in Patients With AF

ROCHESTER, Minn — October 4, 2016 — Researchers have found no significant difference between 3 non-vitamin K antagonist oral anticoagulants (NOACs) for risk of stroke or systemic embolism in patients with atrial fibrillation (AF). However, the study, published online in the journal CHEST, found…

Does OnabotulinumtoxinA Provide Benefits Over Sacral Neuromodulation for Urinary Incontinence?

CHICAGO — October 4, 2016 — A study published in the October 4 issue of JAMA questions whether onabotulinumtoxinA provides a clinically important net benefit compared with sacral neuromodulation for women with urinary incontinence. Women with refractory urgency urinary incontinence are treated…

Lateral-Trendelenburg Position Reduces Incidence of Ventilator-Associated Pneumonia

By Chris Berrie MILAN, Italy — October 5, 2016 — The lateral-Trendelenburg position provides significant reduction in incidence of ventilator-associated pneumonia (VAP) compared with the semi-recumbent position for critically ill patients undergoing intubation, according to a study presented…

Intravenous Immunoglobulin G Provides No Benefit for Patients With Necrotising Soft Tissue Infection

By Chris Berrie MILAN, Italy — October 5, 2016 — Adjuvant intravenous immunoglobulin G (IVIG) has no significant benefit over placebo for patients with necrotising soft tissue infection (NSTI), researchers reported here on October 3 at the 29th European Society of Intensive Care Medicine (ESICM…

Certain LDL-C-Lowering Genetic Variants Associated With Higher Risk of Type 2 Diabetes

CHICAGO — October 5, 2016 — Low-density lipoprotein cholesterol (LDL-C)-lowering genetic variants at the gene NPC1L1 were inversely associated with coronary artery disease and directly associated with type 2 diabetes, according to a study published in the October 4 issue of JAMA. Nicholas J….

Hard-to-Control Asthma Has Distinct Features, Study Shows

CHICAGO — October 5, 2016 — Bronchodilator responsiveness, nasal inflammation, and allergy are among the most significant baseline features that distinguished hard-to-control asthma in inner-city children and adolescents, according to a study published in the Journal of Allergy and Clinical…

Patients With Septic Shock Experience Better Outcomes When Their Heart Rates Were Lower

SALT LAKE CITY, Utah — October 5, 2016 — Patients with a lower heart rate who are in septic shock have a better chance of survival than those with an abnormally rapid heart rate, according to a study published in the October 2016 issue of the journal Critical Care Medicine. Researchers at…

Study Shows Eczema in Children Has Unique Immune Profile

CHICAGO — October 5, 2016 — A study just published in the Journal of Allergy and Clinical Immunology characterises immune changes for the first time in the skin of young children with eczema. “Our findings offer new directions for targeted therapies for children with eczema,” said Amy Paller, MD…

Women’s Better Verbal Memory Skills May Mask Early Signs of Alzheimer’s Disease

MINNEAPOLIS, Minn — October 5, 2016 — Women may have better verbal memory skills than men even when their brains show the same level of problems metabolising glucose, which occurs in people with Alzheimer’s disease, according to a study published in the October 5, 2016, online issue of the…

Adding N-Acetylcysteine to Glyceryl Trinitrate Reduces Infarct Size in Patients With STEMI

By Walter Alexander ROME — August 30, 2016 — Adding N-acetylcysteine (NAC) to low-dose intravenous glyceryl trinitrate (GTN) reduces infarct size and increases myocardial salvage in patients with ST-elevation myocardial infarction (STEMI), researchers reported here at the 2016 Annual Meeting of…

Nebivolol Protects Against Anthracycline-Induced Cardiotoxicity in Patients With Breast Cancer

By Walter Alexander ROME — August 30, 2016 — Treatment with nebivolol protects against anthracycline-induced cardiotoxicity in patients with breast cancer, according to a study presented here at the 2016 Annual Meeting of the European Society of Cardiology (ESC). While anthracyclines are widely…

Alirocumab Can Help Patients With Familial Hypercholesterolemia Reduce Frequency of Apheresis

By Walter Alexander ROME — August 31, 2016 — Patients with heterozygous familial hypercholesterolemia (HeFH) may be able to end or reduce their reliance on lipoprotein apheresis with alirocumab treatment, researchers reported here at the 2016 Annual Meeting of the European Society of Cardiology…

Long-Term Benefit of Drug-Eluting Stents Over Bare Metal Stents Less Than Expected

By Walter Alexander ROME — August 31, 2016 — Patients treated with drug-eluting stents for coronary artery disease do not live longer or better than those treated with bare metal stents, according to a study presented here at the 2016 Annual Meeting of the European Society of Cardiology (ESC)….

FDA Warns About Serious Risks, Death When Combining Opioids With Benzodiazepines

ROCKVILLE, Md — August 31, 2016 — The US Food and Drug Administration (FDA) review has found that the growing combined use of opioid medicines with benzodiazepines or other drugs that depress the central nervous system (CNS) has resulted in serious side effects, including slowed or difficult…

Biomarker Outperforms Current Gold Standard to Detect Brain Shunt Infections

BIRMINGHAM, Ala — August 31, 2016 — In a study of children with brain shunts, an investigational biomarker outperformed the current gold standard test for detecting bacterial infections in the shunts. This is the second potential diagnostic application for the biomarker, said Scott Barnum, PhD,…

Weekly Remote Monitoring of Cardiac Implanted Devices Does Not Improve Outcomes

By Alex Morrison ROME — August 31, 2016 — An attempt to improve mortality and/or reduce hospitalisation among patients with heart failure by monitoring their cardiac implantable devices weekly remotely failed to show a benefit, researchers reported here at the 2016 Annual Meeting of the European…

Sexual Function Problems Occur After MI, Disparities Exist Between Men and Women

CHICAGO — August 31, 2016 — A study published in JAMA Cardiology shows that impaired sexual function or new problems are common after a myocardial infarction (MI). The study showed that sexual problems occur at the same rate as a loss of general physical function and at a higher rate than the…

Study Finds Connection Between Chronic Pain, Anxiety Disorders

BURLINGTON, Vt — August 31, 2016 — New research provides insight into a long-observed, but little-understood connection between chronic pain and anxiety and offers a potential target for treatment. The findings, published in Biological Psychiatry, showed that increased expression of a peptide…

Study Shows Combining Formoterol With Budesonide for Asthma Is Safe

WINSTON-SALEM, NC — August 31, 2016 — A post-marketing safety study mandated by the US Food and Drug Administration (FDA) has shown that a combination drug therapy for the treatment of asthma is safe and effective. The therapy tested consisted of a long-acting beta agonist, formoterol, added to…

Pathological implications of linear immunoglobulin G staining on the glomerular capillary walls in a case of infection-related glomerulonephritis.

We report a 32-year-old man with nephrotic syndrome and preceding symptom of infection. He had renal insufficiency, hypocomplementemia, and elevated titer of anti-streptolysin O. Renal biopsy showed mesangial hypercellularity and focal segmental endocapillary hypercellularity with double contour of the glomerular basement membrane (GBM)…

Nephrotoxicity Associated with Concomitant Use of Ledipasvir-Sofosbuvir and Tenofovir in a Patient with Hepatitis C Virus and Human Immunodeficiency Virus Coinfection.

Direct-acting antivirals (DAAs) have revolutionized the treatment of hepatitis C virus (HCV) infection, with superior efficacy and safety compared to interferon-based therapies…

Pulmonary thromboembolism in patient with coexistence of Behçet’s disease and antiphospholipid syndrome…

Pulmonary thromboembolism (PTE) is rarely reported in Behçet’s disease (BD) due to its distinctive thrombus-forming mechanism. In BD, the inflammation on vessel walls causes venous thrombosis.

An autopsied case of MM1 + MM2-cortical with thalamic-type sporadic Creutzfeldt-Jakob disease presenting with hyperintensities on diffusion-weighted MRI before clinical onset.

A 78-year-old Japanese man presented with rapidly progressive dementia and gait disturbances. Eight months before the onset of clinical symptoms, diffusion-weighted magnetic resonance imaging (DWI) demonstrated hyperintensities in the right temporal, right parietal and left medial occipital cortices…

Muckle-Wells Syndrome: A Case Report with an NLRP3 T348M Mutation.

Autoinflammatory syndromes are a recently described group of conditions caused by mutations in multiple genes that code for proteins of the innate immune system…

Influenza-associated thrombotic microangiopathy with unbalanced von Willebrand factor and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 levels in a heterozygous protein S-deficient boy.

Influenza infections often cause pneumonia, but there is limited information on thrombotic microangiopathy (TMA) in these circumstances…

Intravenous leiomyomatosis treated with radical hysterectomy and adjuvant aromatase inhibitor therapy.

Intravenous leiomyomatosis (IVL), a rare disease that is histologically benign but clinically aggressive, is characterized by the intraluminal growth of benign leiomyoma in the intrauterine and systemic veins…

Autologous hematopoietic stem cell transplantation in combination with immunoablative protocol in secondary progressive multiple sclerosis—A 10-year follow-up of the first transplanted patient.

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that affects young individuals and leads to severe disability…

Presence of Citrullinated Histone H3-Positive Neutrophils in Microscopic Polyangiitis from the Early Phase: An Autopsy Proven Case.

A 76-year-old man was admitted with general fatigue, weight loss, fever, headache, renal failure, and a high serum level of myeloperoxidase-antineutrophil cytoplasmic antibody…

Exercise Results in Larger Brain Size, Lowered Dementia Risk

LOS ANGELES — August 3, 2016 — Using the landmark Framingham Heart Study to assess how physical activity affects the size of the brain and a person’s risk for developing dementia, researchers found an association between low physical activity and a higher risk for dementia in older individuals…

Hysterectomy With Ovary Conservation Doubles Odds of Hot Flushes, Night Sweats

QUEENSLAND, Australia — August 3, 2016 — A study published in the journal Maturitas has found that vasomotor symptoms can persist for more than a decade among women who have had a hysterectomy with ovary conservation, seriously affecting quality of life. Louise Wilson, University of Queensland…

Study Shows Link Between Inflammatory Biomarkers, Increased Heart Disease in Men With HIV

LOS ANGELES — August 3, 2016 — A cardiac imaging study published in JAMA showed a correlation between higher inflammatory biomarkers and an increased prevalence of coronary artery disease (CAD) in men with HIV. Hossein Bahrami, MD, Keck School of Medicine of the University of Southern…

Sleep Disorders May Increase Risk of Stroke

MINNEAPOLIS, Minn — August 3, 2016 — There is growing evidence that sleep disorders like insomnia and sleep apnoea are related to stroke risk and recovery from stroke, according to a literature review published in the August 3, 2016, online issue of the journal Neurology. Based on the review,…

Routinely Measured Lipids Show Contrasting Associations With Risk of CAD, Diabetes

CHICAGO — August 3, 2016 — Increased low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and possibly triglyceride levels are associated with a lower risk of diabetes, and increased LDL-C and triglyceride levels are associated with an increased risk of…

Early Use of Vasopressin Does Not Improve Kidney Outcomes for Patients With Septic Shock

CHICAGO — August 2, 2016 — Early use of vasopressin to treat septic shock did not improve the number of kidney failure-free days compared with norepinephrine, according to a study appearing in the August 2 issue of JAMA. Norepinephrine is currently recommended as the first-line vasopressor in…

Liraglutide Does Not Improve Outcomes for Patients With Advanced Heart Failure

CHICAGO — August 2, 2016 — Among patients recently hospitalised with heart failure and reduced left ventricular ejection fraction (LVEF), the use of liraglutide did not lead to greater post-hospitalisation clinical stability, according to a study published in the August 2 issue of JAMA. Kenneth…

Study Finds No Link Between Sleep Apnoea, Joint Pain in Men

HOBOKEN, NJ — August 1, 2016 — According to a study published in the journal Arthritis Care…

Excessive Alcohol Consumption Impacts Breathing

MAYWOOD, Ill — August 1, 2016 — A study published in the journal CHEST shows a potential new health concern related to excessive alcohol consumption. In the study, adults who drank excessively were found to have less nitric oxide in their exhaled breath than adults who didn’t drink. “Alcohol…

Higher BMI Not Associated With Increased Risk of Myocardial Infarction, Death

CHICAGO — August 1, 2016 — A study of monozygotic Swedish twins suggests that while a higher body mass index (BMI) was not associated with increased risk of myocardial infarction (MI) or death for the heavier twin, it was associated with increased risk for the onset of diabetes for that twin….

Absorption of Intepirdine Not Affected by Food Intake

By Louise Gagnon TORONTO — July 27, 2016 — Intepirdine, a novel selective antagonist of 5-hydrotryptamine 6 (5-HT6) receptors developed for the treatment of Alzheimer’s disease (AD), can be administered with or without food, according to results of a small, open-label, crossover study presented…

Catheter-Based Closure Not Recommended for Patients With Heart Defect, Stroke

MINNEAPOLIS, Minn — July 27, 2016 — An updated recommendation from the American Academy of Neurology (AAN) states that catheter-based closure should not be routinely recommended for people who have had a stroke and also have a patent foramen ovale (PFO). The practice advisory, which updates a…

Combination of Alzheimer’s Drugs Shows No Benefit Over Monotherapy

By Francis Morin TORONTO — July 27, 2016 — Combination therapy for Alzheimer’s disease with memantine with and an acetylcholinesterase inhibitor (AChEI) shows no benefit over monotherapy in the treatment of the disease, researchers reported here at the 2016 Alzheimer’s Association International…

Behavioural Activation as Effective as Cognitive Behavioural Therapy for Treating Depression

NEW YORK — July 27, 2016 — A simple and inexpensive psychotherapy known as behavioural activation (BA) is as effective at treating depression in adults as the gold-standard cognitive behavioural therapy (CBT), and can be delivered by non-specialist staff with minimal training at far less cost,…

Both Door Identification, Amyloid Status Predict Memory Decline in Older Adults

By Louise Gagnon TORONTO — July 27, 2016 — The University of Pennsylvania Smell Identification Test (UPSIT) and amyloid status both predict memory decline in older adults, according to a study presented here on July 26 at the 2016 Alzheimer’s Association International Conference (AAIC 2016). “…

Deprescribing Antipsychotics Is Feasible in Long-Term Care Residents With Symptoms of Dementia

By Frances Morin TORONTO — July 26, 2016 — An innovated program designed to reduce ongoing antipsychotic use in the management of behavioural and psychological symptoms of dementia (BPSD) among long-term care residents shows success in enabling as many as 75% or participants to remain free of…

Cognitive Training in Speed Processing Linked to Reduced Dementia Risk

By Frances Morin TORONTO — July 26, 2016 — Older participants in cognitive training programs focusing on speed of processing show significant reductions in the development of dementia over 10 years, according to research presented here at the 2016 Alzheimer’s Association International Conference…

FDA Says Fluoroquinolones Should Only Be Used for Serious Bacterial Infections

ROCKVILLE, Md — July 26, 2016 — The US Food and Drug Administration (FDA) has approved safety labelling changes for fluoroquinolones to enhance warnings about their association with disabling and potentially permanent side effects and to limit their use in patients with less serious bacterial…

Three- and Two-Drug Regimens Effective, Well-Tolerated in Patients Coinfected With Hepatitis C, HIV

By Frances Morin DURBAN, South Africa — July 26, 2016 — The three-drug, direct-acting antiviral regimen approved for hepatitis C virus (HCV) genotype-1 infection, ombitasvir, paritaprevir co-administered with ritonavir, and dasabuvir (OBV/PTV/r+DSV), with or without ribavirin (RBV), and the two-…

Dual Regimen of Sofosbuvir/Velpatasvir Effective for Hepatitis C/HIV Co-Infection

By Frances Morin DURBAN, South Africa — July 26, 2016 — The fixed-dose, once-daily coformulation of sofosbuvir/velpatasvir is well tolerated and demonstrates efficacy in patients coinfected with HIV-1 and genotypes 1 to 4 of the hepatitis C virus (HCV), according to results of the open-label,…

Predicting Language Deficits After Stroke With Connectome-Based Imaging

CHARLESTON, SC — July 20, 2016 — Mapping damage to the brain’s white matter connections after stroke can predict long-term language deficits, improve the understanding of how language is processed in the brain, and potentially inform a course of rehabilitative therapy that would be more effective…

Infections, Antibiotic Use Linked to Manic Episodes in Patients With Bipolar Disorder

BALTIMORE, Md — July 20, 2016 — Patients with serious mental disorders who were hospitalised for mania were more likely to be on antibiotics to treat active infections than a group of people without a mental disorder. Although the researchers caution that their study does not suggest cause and…

One-Third of Women With ADHD Have Anxiety Disorders, Depression

TORONTO — July 20, 2016 — Women with attention-deficit/hyperactivity disorder (ADHD) have more than 4 times the odds of suicidal thoughts and generalised anxiety disorder and more than twice the odds of major depressive disorder and substance abuse compared with women without ADHD. “The…

Does Hormone Therapy After Menopause Affect Memory?

MINNEAPOLIS, Minn — July 20, 2016 — Contrary to popular belief, taking oestrogen after menopause may not affect the memory and thinking abilities of healthy women no matter when the treatment is started. The study, published in the July 20, 2016, online issue of the journal Neurology, is among…

No Association Between Gadolinium Contrast Exposure, Risk of Parkinsonism

LONDON, Ontario — July 19, 2016 — A study published in the July 5 issue of JAMA has cast doubt on the clinical significance of brain deposits of gadolinium. In 2015, the US Food and Drug Administration (FDA) raised safety concerns over reports of retained gadolinium in the brain for patients…

Chronic Fatigue Syndrome Flare-Ups Caused by Straining Muscles, Nerves

BIRMINGHAM, Ala — July 19, 2016 — A study published in PLOS ONE shows that symptoms of chronic fatigue syndrome can be provoked by imposing a mild to moderate strain to the muscles and nerves. The study included 80 individuals, 60 with CFS and 20 without CFS, who reported their levels of fatigue…

No Significant Difference Found Between Glucose-Lowering Drugs for Risk of Death

CHICAGO — July 19, 2016 — Among nearly 120,000 adults with type 2 diabetes, there were no significant differences in the associations between any of 9 available classes of glucose-lowering drugs (alone or in combination) and the risk of cardiovascular or all-cause mortality, according to a study…

Buprenorphine Implant May Improve Opioid Abstinence Among Adults With Opioid Dependence

CHICAGO — July 19, 2016 — Among adults with opioid dependence maintaining abstinence with a stable dose of sublingual buprenorphine, the use of buprenorphine implants, compared with continued sublingual buprenorphine, did not result in an inferior likelihood of remaining a responder, according to…

Resistant Hypertension May Jeopardise the Heart Health of Patients With Sleep Apnoea

HOBOKEN, NJ — July 18, 2016 — In a study of patients with hypertension, those with resistant hypertension had a higher rate of sleep apnoea (9.6%) than those without resistant hypertension (7.2%). In addition, patients with resistant hypertension with sleep apnoea had an increased risk of…

Study Reveals New Link Between Periodontal, Cerebrovascular Diseases

HOBOKEN, NJ — July 18, 2016 — A study published in the European Journal of Neurology has revealed a relationship between chronic periodontitis and lacunar infarct — 2 common diseases in the elderly. “We observed that people diagnosed with periodontal disease had about a 4-fold increased risk…

Incidental discovery of an unusual right atrial membrane in an adult patient.

We describe presence of an unusual right atrial membrane in a 30-year old female with end stage renal disease, hypertension and peripheral vascular disease…

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